プロテオミクスと酵素学のジャーナル

Potency of Human Interferon β–1a and Human Interferon β–1b in Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy of Encephalomyelitis Disseminate/Multiple Sclerosis (MS) and Hepatitis A, B, C, D, E, F and G Virus Enter and Targets Liver Cells

Alireza Heidari

A novel Glycoprotein–based IFN–α, IFN–β, IFN–γ and IFN–ω superabsorbent was synthesized through sub–cutaneous or intramuscular of 2–methyl–2–propenoic acid, α–methacrylic acid, 2– methylacrylic acid and 2–methylpropenoic acid onto collagen using Ammonium Peroxydisulfate (APS) as a free radical initiator in the presence of N–[(prop–2– enoylamino) methyl] prop–2–enamide as a crosslinker [1-22]. The Cytokines structure was confirmed using 1H-NMR, 13C-NMR, 31P-NMR, Attenuated Total Reflectance Fourier Transform Infrared (ATR–FTIR) and FT–Raman spectroscopies. We were systematically optimized the certain variables of the graft copolymerization (i.e. the monomer, the initiator and the crosslinker concentration) to achieve cytokines with maximum and minimum swelling capacities, respectively. Under the optimized conditions concluded, maximum and minimum capacities of swelling in distilled water were found and computed, respectively. The swelling kinetics and thermodynamics of the synthesized cytokines with various particle sizes was preliminarily studied. Absorbency in aqueous fluoride salt solutions indicated that the swelling capacities decreased with an increase in the ionic strength of the swelling medium. The swelling of super– absorbing cytokines was also measured and investigated in solutions with pH ranges from 1 to 14 [23-44]. On the other hand, Avonex, Rebif and CinnoVexs are the class of pharmaceutical, medical, medicinal and clinical compounds that are widely valued for their pain killing, anti–pyretic, anti– virus and anti– inflammatory properties. The most commonly known and used in Avonex, Rebif and CinnoVexs are Ziferon. They are used extensively