内分泌学と糖尿病の研究

Distribution of ideal cardiovascular health in oldest-old and centenarians and the associations with disability and quality of life: Based on the china hainan centenarian cohort study and China Hainan oldest-old cohort study

Miao Liu

There was lack of data about the distribution of ideal cardiovascular health (ICH) status among the oldest and centenarians, and the association with disability and quality of life was unclear. Hence, this study aimed to analyze the distribution characteristics of ICH metrics status of the oldest-old and centenarians, and also to explore the relationships with disability and quality of life. 1002 centenarians from China Hainan Centenarian Cohort Study and 798 oldest-old from the China Hainan Oldest-old Cohort study were included in the analysis. ICH, disability and quality of life were assessed according to standard methods. The median number of ICH metrics among centenarians and oldest-old were 4 (4-5) and 3(3-5) respectively. The highest proportion of ICH metrics at ideal levels were glucose (90.2%), BMI (89.8%), and smoking (89.4%). The disability rates of BADL and IADL decreased with the number of ICH metrics. The EQ-5D vas, EQ-5D score showed increasing trend along with the number of ICH metrics (p<0.05). Compared with centenarians who had only 0-2 ICH metrics, the ORs for BADL disability were0.82(95%CI:0.48-2.72), 0.66(95%CI:0.19-2.24), 0.52(95%CI: 0.15-1.79), 0.44(95%CI:0.29-1.41), and the ORs for IADL disability were  0.74(95%CI:0.41-1.33), 0.65(95%CI:0.35-1.22), 0.58(95%CI:0.32-1.08), 0.41(95%CI:0.19-0.86) for those with 3, 4, 5, ≥6 ICH metrics among centenarians. The results in oldest-old showed similar trends. In conclusion, the ICH metrics of centenarians and oldest-old were at a relatively good level, and there was a strong and independent inverse relationship between with both disability and lower quality of life.