Glib Yemets*, Telehuzova O. V., Maksymenko A. V., Mankovsky G. B., Marushko Y. Y., Dovgalyuk A. A., Sokol A. A., Yemets I.M.
Aortic stenosis (AS) is a common cardiovascular disease with prevalence in an aging population. There is a growing body of literature that recognizes the variety of treatment techniques based on the morphological and clinical features. Currently, two major approaches in managing patients with AS are widely performed, including Surgical Aortic Valve Replacement (SAVR) and Transcatheter Aortic Valve Implantation (TAVI). Data from several studies suggest that AS is characterized with both genetic and nongenetic causes (the latter include risk factors, namely, age, diabetes, hypertension, obesity, dyslipidemia, smoking, and male gender). Our attention to the correlation between age and aetiology underlying AS. The prevalence of aortic stenosis is age dependent estimated at 1% of those aged over 65 years, 2.5% of those aged 75 years, and 8% of those aged 85 years. Central to the entire concept of AS is the role of key hemodynamic effects which are 1) increased left ventricular (LV) afterload, 2) reduced myocardial compliance, and 3) increased myocardial workload.
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