薬学および新興医薬品ジャーナル

Pharmacokinetics and Drug Metabolism: Interactions and Implications

Maria Leon

Pharmacokinetics and drug metabolism are two fundamental aspects of pharmacology that plays an important role in understanding how drugs interact with the body. Pharmacokinetics refers to the study of how drugs are absorbed, distributed, metabolized, and eliminated by the body, while drug metabolism involves the enzymatic conversion of drugs into metabolites. The interactions between pharmacokinetics and drug metabolism have significant implications for drug efficacy, safety, and personalized medicine. The process of pharmacokinetics begins with drug absorption, where a drug enters the bloodstream from its site of administration. The route of administration, such as oral, intravenous, or transdermal, influences the rate and extent of drug absorption. Factors such as solubility, molecular size, and pH conditions can affect the absorption process. Once in the bloodstream, the drug is distributed throughout the body, where it interacts with various tissues and organs. The distribution of a drug is influenced by factors such as blood flow, tissue permeability, and protein binding