Zhao Huang*
The World Health Organization has identified major depression as a main cause of disability globally. It is a prevalent and often fatal condition. While antidepressants are unquestionably helpful in roughly 70% of cases, a significant number of individuals remain partially or completely unresponsive to treatment. Treatment resistance has no easy explanation; however it is possible that modern antidepressants do not adequately address all of the pathogenic mechanisms that cause the primary symptoms of depression. As a result, there is a pressing need to widen the range of targets on which antidepressants are thought to work [1].
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