With a focus on human integrative and translational physiology, we publish original research that is considered likely to further our understanding of the functioning of the intact healthy human body under a variety of environmental (e.g. altitude, climatic, gravitational) and exercise conditions. However, the boundaries of physiology have enlarged as demarcations between concepts and techniques in the physiological, pharmacological, and biochemical sciences become increasingly blurred. Moreover, theoretical articles on research at any level of biological organization ranging from molecules to humans fall within the broad scope of the Journal. In all areas of applied physiology, the use of cutting-edge techniques including molecular and cellular biology is strongly encouraged.