Praneeth Rao Kakulamarri, Kanaka Latha Alikatte and Uday Venkat Mateti
Transdermal Iontophoresis of Non-Polar Drugs: A Mini Review
Abstract
Transdermal iontophoresis is one of the most studied active technique involves passage of small electrical current to drive the charged drug molecules through the skin. However, iontophoresis is not suitable for nonpolar drugs as they lack any charge and possess poor water solubility. Therefore, the main objective of this review was to discuss the potential approaches to render the lipophilic drugs amenable to iontophoretic delivery across the skin.
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