薬剤学および薬物送達研究ジャーナル

The Release of Tacrolimus from a Cotton Biomaterial to Dermis

Oana Parteni, Cezar Doru Radu, Ion Sandu, Ioan Emil Muresan, Lacramioara Ochiuz, Eugen Ulea and Cornel Munteanu

The Release of Tacrolimus from a Cotton Biomaterial to Dermis

Abstract

Objective: The paper describes the creation of a delivery system for a drug with high dimensions, as tacrolimus.

Methods: The achievement of a biomaterial manufactured of alternative layers of chitosan (CS) and sodium alginate (Alg) with the inclusion of tacrolimus (Ta) between layers. By the gradual dissolution of layers, Ta is released.

Results: On a cotton fabric, it has been performed a biomaterial consists of 10 layers of CS and Alg. The biomaterial can sustain and then release Ta according with a specific relase kinetics and by avoiding “burst effect”. The following have been evaluated: coated fabric loading degree, the number of charges on the specific surface, the dyeing tests, the Ta kinetic release and the elemental analysis (EDAX). The method proposed describes the advantages of releasing the drug as well as the limits imposed by using other systems for controlled drug release, such as cyclodextrins or hydrogels.

Conclusion: In paper, the proposed biomaterial is a viable alternative for regular treatments of cutaneous diseases with a Ta formulation supported from a textile fabric for psoriasis.