臨床および実験放射線学のジャーナル

Hsa_circ_001783 regulates breast cancer progression via sponging miR-200c

Chang Gong

Increasing evidence suggests circRNAs exert vital functions in tumor progression via sponging miRNAs. However, the role of circular RNAs in breast cancer remains mostly unclear. Here we reported the molecular mechanisms of a novel circRNA, hsa_circ_001783 in regulating breast cancer progression and its ability in predicting clinical outcomes by integrating high throughput computation, experimental technologies in vitro and clinical investigation. Our computational pipeline identified hsa_circ_001783 as the one with highest score out of 594 breast cancer-associated circRNA candidates. We found the circRNA was enriched in cytoplasm and overexpressed in breast tumor as compared to paired non-cancerous tissue. High expression of hsa_circ_001783 correlated with higher tumor burden (p=0.047) and poor overall survival (p=0.025) in128 patients. Knockdown of hsa_circ_001783 remarkably inhibited the proliferation and invasion of MDA-MB-231 and MDA-MB-468 cells.