Thomas Kipping and Hubert Rein
Development of Extruded Starch Based Formulations Aimed for Local Drug Delivery to Oral Cavity
The suitability of different starches as a basic substance for a prolonged release oral dosage form was evaluated. Starches were extruded slightly above gelatinization temperature. The shape of the melt was predetermined by a slot nozzle. Circular, tablet like single dosage forms were produced by manual die-cutting of the still elastic strands. Five different starches were used as basic substances: corn starch, pea starch, potato starch, high-amylose corn starch Eurylon®5 and amylose-free corn starch Waxilys®200. Menthol and clove oil were used as active ingredients. Physical characteristics were analyzed to prove storage stability of the products.
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