医療バイオテクノロジーのアーカイブ

Animal Model for Glioma: A Brief Overview

Phanithi Prakash Babu and Ravindra Pramod Deshpande

Glioblastoma remains the most aggressive malignancies of the brain with dismal prognosis. Typically, it is pathologically characterized by nuclear polymorphism, cellular atypia, necrosis and aggravated angiogenesis. Recently, the 2016 WHO classification, has however given impact on profiling of molecular markers as IDH, EGFR for better prognostic assessment. Animal model are needed to recapitulate the pathology of naturally growing tumors to develop and update the therapeutic regime. Present review provides a glimpse of molecular pathology of glial tumors and the existing animal models being used for glioma research.