老化と老年医学ジャーナル

The Effect of Serum Sex Steroidal Hormones, on Prostate Volumes of Benign Prostatic Hyperplasia Patients with Different Levels of Serum Testosterone

Masanori Nukui, Hitosi Takada and Shuichi Nakagawa

Introduction: The effect of serum steroidal sex hormones on benign prostatic hyperplasia was evaluated with different levels of serum testosterone epidemiologically.

Methods: Between April 2015 and February 2017, 194 patients attending our urological clinic were assessed for the relationship between prostate volume (PV) and, serum sex hormones (testosterone (T), dihydrotestosterone (DHT), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS)), and between PV and physical size, personal habits, etc. PV was measured by using trans–abdominal ultrasonography. Statistically, the Pearson correlation coefficients test was used.

Results: Total cases (194), the cases of T<3.5 ng/ml (51), the cases of 3.5 ≦ T<5.5 ng/ml (85) and the cases of T ≧ 5.5 ng/ml (58) were evaluated respectively. Total cases and the cases of T<3.5 showed a positive significant correlation with E2, but the cases of 3.5 ≦ T<5.5 and T ≧ 5.5 showed no such correlation. The cases of T ≧ 5.5 had a positive significant correlation with T/DHEAS, DHT/ DHEAS, E2/DHEAS and age, but the cases of 3.5 ≦ T<5.5 showed only correlation with E2/DHEAS.

Conclusions: The PV of lower serum T level was affected especially by serum E2. The PV of higher serum T level was correlated with age or DHEAS. Basically, androgen affects PV, however, it seems to work in cooperation with other sex hormones in different ways depending on the serum androgen level.