肝臓ジャーナル: 病気と移植

Portal Vein Ligation for Staged Hepatectomy in a Rat Model of Liver

Martin Simmering

Associating liver dividing wall/ Associating Liver Partition and Portal vein Ligation for staged hepatectomy (ALPPS) in a rat model of liver disease has not, to the best of our knowledge, been before that/ before now examined something closely so the truth can be found. The currently study therefore aimed toward begin a model of ALPPS in cirrhotic rats and to test/evaluate liver regeneration. Rats were haphazardly alienated into an ALPPS collection through carbon tetrachloride-caused liver disease (group A) and a commonly and regular/ healthy liver (group B). Rat weight, cytokine levels, related to the chemicals in living things limits/guidelines and histopathology were tested/evaluated ALPPS. Higher aspartate aminotransferase and alanine aminotransferase levels were noticed in group A on the first after an action day. On the first, second and third days, hepatocyte growing and spreading rate was higher in group B than in group A. After these days, hepatocyte increasing and spreading rate in group B activated to decrease, but the rate in group a continual to increase until the day. Higher levels of hepatocyte growth factor, interleukin-6 and tumour death of skin or other living tissue factor‑α were detected in group A compared with group B, but the differences were not sign tilt/language. The present study showed/shown or proved that ALPPS helped increase/showed in a good way liver regeneration in a rat model of liver disease, but significantly damaged/weakened liver function. Compared with the ALPPS model, group B showed a delayed peak of growing and spreading. The technique of liver renewal shaped by ALPPS in cirrhotic rats might be associated by better cytokine levels.