薬物中毒と解毒：新たなアプローチ

Defining the Role of Single Nucleotide Polymorphic (SNP) in Drug Development and Toxicity

Rais A. Ansari

Defining the Role of Single Nucleotide Polymorphic (SNP) in Drug Development and Toxicity

The sequencing of human genome has lead to define the variations among humans, which is quite astonishing. Before sequencing of human genome, variant among genes were observed as mutations.It was known that mutations in key regulatory and functional genes cause diseases. With the advent of single nucleotide polymorphism (SNP) among genes, which is believed to be present in every 1.0 kb in human genome (3X106 SNP in 3X109 bps genome), has changed the very paradigm of disease progression, drug action and toxicity.